Diabetes, the medical condition of persistently high blood sugar, is driven by critical deficiencies in five things: genes, nourishment, sleep, exercise, and stress management and diabetes is exacerbated by various excesses. Ironically, one such excess is the high sugar diet [300 grams of carbohydrate a day!] recommended by the American Diabetes Association.
In the etiology of diabetes, while deficiencies drive the process, one possible contributing excess is the consumption of vast amounts of sugars in brief periods of time, forcing the body to process sparingly soluble amylin precursor proteins faster than it can safely do so; as insoluble junk accumulates, insulin producing cells can be killed off prematurely, one of many routes to type II diabetes.
Undernourishment is one of the 5 drivers of medical conditions, the precursors of disease and death.
In America, undernourishment is often accompanied by overfeeding. Undernourishment fails to shut off the hunger drive until the next meal, and when food is readily available, this awakened hunger (along with stress, lack of sleep, and insufficient exercise) contributes to overfeeding.
Hence the mistaken notion of American doctors that obesity is a risk factor for type II diabetes, a notion that often borders on the ludicrous assertion that obesity causes diabetes. No Indian doctor would that mistake because:
In India, undernourishment is rarely accompanied by overfeeding.
Consider this article:
Incidence of diabetes highest, progression fastest among Asian Indians
Anjana RM, et al. Diabetes Care. 2015;doi:10.2337/dc14-2814.
April 30, 2015
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Asian Indians with prediabetes exhibit one of the highest incidence rates for diabetes, despite being younger and having a much lower average BMI than other high-risk populations, according to research in Diabetes Care.
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The follow-up study of a large population-based epidemiologic study of adults in south India also showed that progression from prediabetes to diabetes occurs much faster in Asian Indians than in other ethnic groups, according to researchers.
Ranjit Mohan Anjana, MD, vice president of Madras Diabetes Research Foundation in Chennai, India, and colleagues at other institutions analyzed data from 1,376 participants of the Chennai Urban Rural Epidemiology Study (CURES) cohort with a normal glucose tolerance (n = 1,077) or prediabetes (n = 299) at baseline, who were followed for a median of 9.1 years. Participants completed interviewer-administered questionnaires at both baseline (between 2001 and 2003) and follow-up (between 2012 and 2013) regarding their socioeconomic status, medical and family history, physical activity, and tobacco and alcohol use. Researchers measured BMI, waist and hip circumference, blood pressure and glucose levels. Researchers checked cases of self-reported diabetes against medical records for accuracy.
Among participants with normal glucose tolerance at baseline, 19.4% developed diabetes and 25.7% developed prediabetes. Among participants with existing prediabetes, 58.9% went on to develop diabetes.
The incidence rate of diabetes for the cohort was 33.1 per 1,000 person-years (95% CI, 29.9-36.5), whereas the incidence rate for prediabetes among those with a normal glucose tolerance at baseline was 29.5 per 1,000 person-years (95% CI, 26.1-33.1).
The incidence rate for prediabetes for the cohort was 78.9 per 1,000 person-years — higher than rates reported in small, isolated populations, such as the Pima Indians, the Micronesian population of Nauru and Native Americans participating in the Strong Heart Study, according to researchers.
“Part of this could be explained by the high prevalence of family history [of diabetes] in our population,” the researchers wrote. “It also represents rapid epidemiological transition in our population.”
Those in the cohort with normal glucose tolerance who went on to develop diabetes were significantly older and had a higher BMI, waist circumference, systolic and diastolic BP and insulin resistance compared with those who did not develop the disease. Those in the cohort with prediabetes who developed diabetes had a significantly higher fasting plasma glucose, 2-hour plasma glucose and HbA1c level, and they were more likely to have a family history of the disease than those who did not progress to diabetes, according to researchers.
“Awareness of the predictors of incident diabetes will help in the identification of individuals at highest risk so that appropriate preventive measures could be taken to slow down the epidemic of diabetes in this population,” the researchers wrote. – by Regina Schaffer
Disclosure: The researchers report no relevant financial disclosures.