RNY gastric bypass: in those cured of diabetes, is this evidence for high level duodenal gluconeogenesis?

In the 80% or so of those who are cured of diabetes shortly after RNY gastric bypass and long before significant weight loss:

Could at least part of the explanation be that in these patients, a high level of constitutive gluconeogenesis was occurring in their duodena or a key regulatory/stimulatory event in gluconeogenesis, or both?

At any rate, causation is out of the question. Causation is an over-used, inane, insane function of one variable.

Enough gluconeogenesis to account for most of the excess glucose found in their bloodstream after an overnight fast?

At any rate, more gluconeogenesis than is commonly recognized. Doctors believe that in general the liver does most of the gluconeogenesis, followed by the kidneys, followed by the intestines. Perhaps in most healthy individuals and when gluconeogenesis is not constitutive.

But in everyone else? I doubt it.

In hypothesizing that Simpson’s Paradox is the rule

I am really saying –

Rule 1: as a rule, there is/are one or more hidden variables in scientific treatments. People tend to oversimplify, initially treating the phenomenon as a function of too few variables, often just one, the cause.

Rule 2: as a rule, these hidden variables are confounding – they make Simpson’s Paradox the rule. The correlations observed would dissolve or become considerably less meaningful, as soon as the hidden variable(s) is/are uncovered and properly understood.

Mental illness – so unlike physical illness

About 1/3 of Americans have high blood pressure (systole >140). Most Americans do not have high blood pressure. Similarly for type II diabetes and I should guess most illnesses. Most Americans do not have ‘X’, where ‘X’ is a serious medical condition or illness.

Mental illness is different.

Mental illness is not rare. It is not the exception.

Just the opposite. Mental illness is the rule (more than half, may be much more) – because NOT to be mentally ill, so many things have to be right or nearly so, and this is unlikely, given our present predicaments.

Mental illness also has a scope that is broader than currently recognized. For one, mindless aggressiveness (aggression without reason), so common in today’s world, and likely somewhat less common in the past, is a form of mental illness. For another, suicide is much more common than is currently recognized by the working definition, and because this is the most aggressive form of aggression toward self, that mental illness is underestimated.

Mental health is exceptional. Anyone who is mentally healthy may be one in a ten, or one in a hundred, or one in a thousand. I just don’t know how prevalent mental illness is.

Mental illness is one of the drivers of accelerated ill health. If a person gets type II diabetes in his/her 60s, that is not indicative of serious mental illness. But some children and adolescents who develop type II diabetes have underlying psychiatric ills that create ‘executive deficits’ in decision-making (and human judgment, as I have argued, is generally poor) and accelerate their decline in health. Again, the establishment is in denial of this. The authorities do not even see the widespread nutritional deficits let alone the mental health deficits.

Restatement: the winter hypothesis

In the northern hemisphere:

People born between Samhain and Beltran (“winter children”) are more likely to have psych problems, including serious psychological illnesses, than those born between Beltran and Samhain (“summer children”).

Summer children who have serious psych problems are weaker people, people who cave in under ordinary, everyday type of pressures, and some are people who have suffered considerably more than any ordinary levels of trauma.

The lost prognosticator of poor health

As markers go, I would like to evaluate oral health, and compare it to what we are currently using. I’ll bet poor oral health is better than high cholesterol as a harbinger of bad health. Dentists and doctors do not share data: too bad – the cross-fertilization potential is significant.

As deficiencies are one of the major types of hits in the multi-hit a-causal model of disease: If the salivary glands have low priority on key nutrients, then saliva is one of the better places to look for local nutrient deficiencies, much better than both the vital organs and the circulatory system (whose deficiencies in part explain high cholesterol, high blood pressure, and even high blood sugar), both of which have to have a higher priority on limited nutrients.