- If the body was trying to get rid of cholesterol, it would make it more water soluble, and excrete it in urine. Further derivatization of cholesterol sulfate would be a good start. Failing this, the body would metabolize the cholesterol into a product the body could not reabsorb in the gut.
- The body would not excrete in bile unaltered cholesterol upstream of its absorption/reabsorption site.
- If the body were trying to get rid of excess cholesterol, the body would not absorb up to one gram of dietary cholesterol.
- The body would not reabsorb nearly all of its bile (~95% on average), as excreting bile would be an excellent way to reduce bodily cholesterol.
- The body’s efficient absorption of cholesterol precursors like squalene is not consistent with the medical hypothesis that biliary cholesterol is a waste product.
These basic facts of physiology argue for a different role for cholesterol and other lipids in bile: that of the seed lipid, that allows us to absorb more of fat soluble substances when the ingestate has very little lipid.