About mljczz

I received a Ph.D. in Biochemistry in 1983 from The Ohio State University. After a sixteen year career researching and developing rapid, ultra-sensitive, quantitative DNA probe assays for the diagnosis and prognosis of deadly diseases, I have been researching and developing meals with optimal nutrition since 2000. Along the way I have also published many other books dealing with nutrition and general philosophical issues. See my Amazon, my Barnes and Noble, or my Smashwords links.

There are three or four nutritional requirements for each nutrient, essential and non-essential

The US government’s single nutrient requirement for each essential nutrient, with no more variation in the recommended amount other than by age, sex, and body size, and their mistaken idea that all non-essential nutrients have no nutritional requirements (amount required = 0 for all of them) for the maintenance of good health is too narrowly conceived, if not downright erroneous.

Example vitamin C. There are at least three separate nutritional requirements.

Requirement No 1 – the minimum requirement, the amount necessary to avoid scurvy. Roughly 10 mg per day.

Requirement No. 2 – the RDA, about 100 mg per day, the amount required to support basic immune and antioxidant functions, and enough to maintain bodily pools at these levels.

Requirement No. 3 – the optimal amount, approximately the amount the body is trying to absorb, which depends on conditions, more when we are sick (colds and flus), and much more when we are very sick (cancer cachexia). This is the amount needed to keep the body’s mucus flowing smoothly, by thinning the body’s entire lining of mucus, and is grams per day. It will not prevent a cold, but if you get a cold, you will find considerably more relief from about 3-6 grams a day, as per Requirement No. 3, than from the 100 mg of Requirement No. 2.

Similarly for all other nutrients, both non-essential and essential. If the body makes specific receptors for any nutrient, it is important to health, even if the body already makes a make-do amount. Some adverse consequence, perhaps psychiatric (who notices these, given that moderns are rather crazy to begin with?), perhaps only distantly related to the shortfall, will ensue, if one does not give the body what it is looking for, and that includes cholesterol and non-essential fats.

At least three levels, with the optimal level often close to what the body is trying to absorb. An obvious exception: the body is trying to absorb considerably more of certain nutrients like Na+, Cl-, and I-, and the explanation may be in the deep evolutionary past. We must give the body at least the first level of these nutrients, although the body will clearly take up to at least the third level of these nutrients.

Similarly for iodine/iodide. While the US RDA of 150 micrograms of iodide is generally enough to keep the thyroid gland functioning properly, it is not enough for breast health, and probably not enough to meet the requirements for brain health and oral health. The body is trying to absorb milligrams of Iodide, and that is nearer the optimum amount. Some experiments of Dr. Guy Abraham suggest that the body will readily absorb nearly 50 mg of an iodide/iodine mixture (since about 45 mg per day is excreted in a 24 hour urine), even when its thyroid is well-supplied with iodide.

As noted above: with NaCl, the body goes after iodide with abandon. No doubt the system evolved under stresses of rather severed deprivation, and this aggressiveness in the absorption of these nutrients is not really necessary when there is such abundance available to us that we have to be sensible in the amount of Na+, Cl-, and I- we give to our bodies.

When 150 micrograms of iodide a day is not enough for thyroid: when a person is overdosed with goitrogens, like F, Br, SCN, ClO4. For example, some people consume so much bromated white flour products that they have to be dosed with milligrams of iodide a day to compete with Br- for uptake at the sodium iodide symporter and to compete with Br- for oxidation by thyroid peroxidase in the thyroid follicle lumen, along with about 10 grams of NaCl per diem to drive the excess Br- into the urine, as in the protocol of Dr. Guy Abraham. He also uses 3 grams of vitamin C a day to help prevent oxidation of the halide binding site in the sodium iodide symporter (more of a problem when F- and ClO4- are also present at levels that interfere with normal thyroid function).

 

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A brighter future requires brighter gatekeepers

Innovators are often small fry. Sometimes they do not even have college degrees, but they can see how to make things better, while layer upon layer of management does not.

As a rule, gatekeepers are neither innovative nor bright. They will not fund a novel idea unless their boss somehow likes it, and bosses of gatekeepers were once gatekeepers themselves, equally or perhaps more uninspiring., and some of them were promoted in part because of their tight-fisted control of the budget.

Gatekeepers tend to be clueless. That is why we have hundreds of such follies as the ubiquitous foxes guarding henhouses, superfund cleanup sites, speed bumps, audible car alarms, squeezable mayonnaise, brominated flour, 100% locally grown produce, choline-is-not-an-essential-nutrient-until-1998, and dietary-cholesterol-is-still-a-toxin. Gatekeepers cannot see the follies that we innovators immediately detect. We are bright sparks; they are not.

Until innovators hold the purse strings, the future of the world remains dim at best.

If you are a CEO and an intelligent risk taker, try giving a few purse strings to innovators or former innovators rather than to toady gatekeepers.

A crude estimate of liver insufficiency in America

Liver insufficiency is not liver disease. It is just some kind of liver metabolic insufficiency or impairment due mostly to poor stewardship of the body.

Roughly 20-25% of Americans have a noticeably higher serum cholesterol after a month of consuming 3-5 eggs a day.

Roughly 75-80% of Americans have approximately the same serum cholesterol after consuming 3-5 eggs a day.

Crude estimate of liver insufficiency in America: 20-25%, could be higher, as these data focus on proper bile production from dietary cholesterol, choline, and taurine, and successful bile secretion, i.e. no backup of dietary cholesterol (and/or bile acid salts) into the circulatory system, nearly all dietary cholesterol being confined to enterohepatic circulation in healthy individuals.

The prevalence of liver insufficiency should be considerably greater than the prevalence of cirrhosis, which is estimated to be less than 1% in the US.

The Epidemiology of Cirrhosis in the United States: A Population-based Study.

PMID: 25291348

CDC stats on the prevalence of all types of liver disease:

  • Number of adults with diagnosed liver disease: 3.9 million
  • Percent of adults with diagnosed liver disease: 1.6%

https://www.cdc.gov/nchs/fastats/liver-disease.htm.

Still a fraction of the number I am estimating, closer to 20%. Are their tests not sensitive enough to see real metabolic problems in liver?

Or is my estimate utter nonsense?

 

 

 

 

Nature plays with fire

Imagine a nutrient so vital that nature keeps its concentration near its saturation limit. Imagine further that when this nutrient massively precipitates in the kidneys (as during an episode of tumor lysis syndrome, when tumor cells are killed too rapidly and release massive amounts of uric acid from the breakdown of nucleic acids), it can actually kill a person. Doctors of course will treat this vital nutrient as a toxin.

As a rule, doctors think of the marvelous machine, the human body, as a right idiot. As a rule, doctors misunderstand everything they study.

When nature plays with fire, pay attention – the fire is so important as to be vital to health. We have to be proper stewards of our bodies. We have to give our bodies what they need and not a whole lot else.

The fire is not a toxin, and many factoids will tell you that this fire is not a toxin, if you do not filter them out of your interpretation, the ways doctors routinely do, whenever matters get a bit too intricate for them.

Synovial fluid is an ultrafiltrate of plasma. Its normal concentration of uric acid is roughly the same as plasma, nearly twice that in whole blood.

The normal concentration of uric acid in the synovial fluid of the average man is close to the saturation limit of uric acid in pure water at 25 degrees C. The solubility limits are not the same. Synovial fluid is not water, and biological tissues, even extremities like big toes, do not normally reach down to 25 degrees.

And even when saturation has been reached, crystallization does not necessarily and immediately occur. Often agitation is required to crystallize a supersaturated mixture. The stubbing of a big toe may be just the thing to trigger it.

When a toe is wounded, as part of the healing process, the marvelous machine acidifies the site of the wound, increasing the odds of precipitation of the uric acid as sodium urate.

Keeping external wounds properly acidified to aid healing and to keep infection risk as low as possible is something doctors pay too little attention to. Take a lesson from the marvelous machine, doctors! Ascorbic acid and citric acid are two acids I would try to apply repeatedly to every external wound during the healing process.

An infection in or near synovial fluid that produces acid could trigger precipitation, as could a non-acid producing infection that produces a sufficiently acidic response in the host. When the cells that line the synovial joint are injured or actually die, they release uric acid. This could be part of the trigger mechanism for precipitation of uric acid crystals in synovial fluid.

Whatever explains a particular case of gouty arthritis, one focuses on the site of occurrence. One does not treat circulating uric acid as a toxin, when kidney reabsorption alone says otherwise, and one does not refer solely to systemic events to explain local occurrences. Local occurrences occur because local conditions are in some way different from systemic conditions. Systemic conditions feed local occurrences, but the local situation is always at least subtly different. Small differences matter. Many small differences matter a lot.

Correlations are not causes

Consider the following possibilities:

  1. Higher organisms have better DNA repair and live longer than lower organisms. A correlation exists but it is neither causal nor contributory (neither a major nor a minor contributor).
  2. Higher organisms have better DNA repair than lower organisms, and in part because of this, live longer. Better DNA repair contributes to or drives (is the major contributor to) greater longevity.
  3. Higher organisms have better DNA repair than lower organisms, and solely because of this, live longer. Better DNA repair is the sole cause of their greater longevity. DNA damage is solely responsible for senescence and death.

Of the three possibilities listed, #2 is the most likely. The effect on longevity might be small, medium, or large. The best experiment is hard to do:

  1. Create a sufficiently large cohorts of different types of higher organisms whose DNA repair is no better than that of a mouse, and compare their longevity with mice and with other members of the higher species whose DNA repair is wild type. If possible, change nothing else. Of course, it is not possible to change nothing else. Intrinsic complexity rules! Interpretations are always suspect even when most people think they are crystal clear.

Rule: scientists lack imagination

Most scientists have sufficient intellectual discipline, but lack imagination and intellectual honesty. They conceive of phenomena too narrowly, often causally, when there are correlations that are better modeled without invoking causation, and lacking intellectual honesty, when their personal agendas are satisfied, scientists are satisfied with views that are flat-out contradicted by other data.

Philosophers, artists, and saints – Nietzsche’s triad of worthy human beings, scientists deliberately excluded – have too much imagination and not enough intellectual honesty and intellectual discipline.

Is there any person in the history of our world who has intellectual discipline, intellectual honesty, and sufficient imagination? Will there ever be?

To be in my list of worthy human beings, minimally, all three are required. I am still looking for an example.

Rule: Correlations are not causes

Hyperuricemia correlates most strongly with gout and less strongly with a number of other medical conditions, including elevated BP and elevated blood sugar.

Is hyperuricemia the cause of any of them?

No – but the underlying problems, kidney and liver insufficiency, are contributors to all of them.

Kidney and liver insufficiency are short of outright diseases and are more common than outright diseases.

A healthy liver balances the toxic loads on the body. It directs a portion of the toxins toward the circulatory system, the kidneys, the ureters, the bladder, and the urethra, and each of these things suffers the consequences, depending roughly on the product of the toxicity per unit concentration, the concentration of the toxins, and the time spent in contact with these organs/tissues. The liver directs the rest of the toxins to the gall bladder, which stores and concentrates the toxins, taking a real beating, to the small intestine, large intestine and the anus. Nothing gets the full load of toxicity that the liver was processing.

Any degree of liver insufficiency can increase total toxicity and exacerbate problems with the body’s management of total toxic loads and especially unbalanced toxic loads,

Kidney insufficiency increases the concentration of a large number of circulating toxins, and of some nutrients (the kidneys do not ordinarily reabsorb 90% of toxins; they do ordinarily reabsorb 90% of uric acid in the filtrate, consistent with uric acid being a nutrient, whose concentration in blood will rise when kidney filtration is subpar), like uric acid, and thus all sorts of medical conditions will correlate with kidney insufficiency. It is a real problem, a real menace to health.

High circulating uric acid, due mostly to kidney insufficiency, increases the odds of gout. But gout starts long before that with the development of an arthritic joint, itself a long and complicated tug of war process, followed by some kind of injury (like stubbing the toe), or insult (a recent surgery), or an infection in or near the joint, (could mild acidification of the joint be a common denominator in these triggers?) and given kidney insufficiency, too high a concentration of uric acid increases the odds of an acute gouty attack, most often in one synovial joint of one big toe.