The multi-hit a-causal model of disease says that the problem, the enemy, is us, more specifically, our weaknesses.
Koch’s postulates have the wrong emphasis – it is them, not us. They cause disease and we suffer the consequences.
Our defenses, both specific and non-specific, should be the focus of research.
Pathogens are challenges, and little more, but they evolve. What works today against these pathogens will probably not be adequate in time.