- Enterically coated probiotics might create toxins when taken with meals – if they metabolize bile acid salts the wrong way.
On the other hand, when taken during fasting, many bacteria may die during the journey to the colon, but at least they wont be metabolizing bile acid salts and the more robust ones may still survive long enough to do some good. In addition, probiotics are suboptimal as a stand alone. Proper diet can restore a better balance among the flora as long as there are some of the more favorable bacteria already there.
In sum, what we need: properly formulated probiotics, possibly with their own nutrients, their prebiotics, taken at the optimal time and combined with optimal diet.
Current formulations and current protocols for taking them are seriously suboptimal.