Repair of higher order structures in mitochondria

Previously, I suggested that the slight increase in total energy produced when a cell is doing high level mitochondrial respiration as compared to substrate level phosphorylations may be energy that is more available for discretionary processes like the repair or replacement of damaged higher order mitochondrial structures.

What if that is not true? Suggestion #2: the main trigger for repair or replacement of these structures may be oxidative damage itself, as opposed to all other types of damage, and without high level mitochondrial respiration, there is less oxidative damage to these structures, and though plenty of other damages, these other damages not being major triggers of repair and replace mechanisms, the damaged structures then tend to persist to the degree that mitochondrial respiration is bypassed for sugar fermentation and other substrate level phosphorylations.

 

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s