One or more things are in excess locally and one or more things are deficient locally – the combination is a formula for disease at a specific locus at a particular time.
Inflammatory bowel disease – excesses of noxious things (and rarely excesses of helpful things) are living in the bowel even as a portion of them is passing through the bowel (a marker of the problem), and at the same time deficiencies in helpful things are present in the bowel and a deficiency of them is passing through (a marker of what is wrong). When some of these two types of substances are generally known, it is our fault that this is happening to us. We are far from victims. Our wounds are so self-inflicted.