Dissecting ADME

  1. “ADME” stands for Absorption, Distribution, Metabolism, and Excretion.
  2. All nutrients have their own ADME network. Together, all nutrients make a huge interdependent web-like network. No nutrient stands alone. All attempts by science to treat nutrients as stand alone are off the mark.
  3. A & D — these two convert dietary nutrients into nutrients available to the body. A & D work together to temporarily increase total bodily pools.
  4. M and E — these two work together to decrease the bodily pools of nutrients.
  5. The ADME network thus works together to maintain bodily pools of each nutrient (and there are thousands of nutrients in the body) in the optimal range, as best as it can.
  6. The sum total of all of the nutrients’ ADME networks is a network of networks, thoroughly interconnected, or hopelessly entangled (to those who attempt a mathematical treatment).
  7. In some cases, the term “metabolism” is either undefined or metabolism is defined in an unusual manner. For example, how do we define the “metabolism” of ions that exist in only one valence state? Here we distinguish all of their complexes from free ions that bind only water. For example, we can define Mg++ (free) + X– = MgX, where X– is anything that complexes Mg++, excluding water, such as ATP, citrate, sulfate, proteins, etc. as the metabolic reactions of Mg++. After all, the un-complexed (that is, complexed only with water) concentration of a nutrient can be the key to understanding changes in concentration within a compartment. A tiny change in total concentration can be a major change in the concentration of the “un-complexed” and thus “more reactive” species.
  8. Because of the above, even when a nutrient is in excess, it may be in excess because of a deficiency of another nutrient obtained from the diet that is involved in its M or its E, or a nutrient that negatively regulates its A or D.
  9. Thus, in some cases, consuming foods containing nutrients, including those which are already in excess in the body, can help rebalance a nutrient already in excess by simply supplying more of its M or E network nutrients or more of nutrients that negatively regulate its A or D.
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