What’s killing us

One thing: our terribly imperfect human genome. It seems that in evolution slow breeding, longer-lived species almost inevitably lose out in competition with faster breeding, shorter lived species. And as a result of evolutionary selective pressures, we suffer the consequences of aging and death, and we note the contradictory importance of two more things that would spell our demise even if our genome were quite a bit improved with respect to maintenance/repair: oxidation and lack of oxidation. The former is the penalty we must suffer just to have abundant energy from mitochondrial respiration and the latter is the penalty we suffer when we don’t do enough mitochondrial respiration, and we lose measurable respiration capacity with each passing decade of life.


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