This certainly goes for vitamin C: in anti-oxidation, vitamin E takes the first insult in membranes, is detoxified by CoQ10 or vitamin C, the respiratory chain detoxifies CoQ10, glutathione detoxifies vitamin C, and glutathione reductase and NADPH detoxifies glutathione. Food consumption and the PPP and several other shunts keep NADPH at healthy levels. Energy/NADPH is the ground zero antioxidant in cells.
Studies on the effects of vitamin C even just as an antioxidant do not look at the whole network and thus are beside the point. What good does a massive infusion of vitamin C do, when the other network antioxidants are not properly supported?