When is a sensor not a good sensor?

When it is poisoned by excesses of harmful reagents and when it is starving for nutrients essential to its function.

An example: when is an oxygen sensor not a good oxygen sensor?

When oxygen is plentiful and the oxygen sensor “thinks” it is not because of either of the above problems.

Is a critical deficiency for the HIF oxygen sensor vitamin C? Can iron deficiency, alpha-ketoglutarate deficiency, and succinate excesses also be problematic to the function of this sensor? We know von Hippel Lindau factor deficiency is a problem as far as turning over HIF when oxygen is plentiful, and no doubt the proline hydroxylase deficiency is as well.


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