Reducing sorbitol in the cells of diabetic patients

Diabetics likely excrete taurine in urine secondary to kidney damage and to a buildup in sorbitol in their tissues from glucose overload in cells. The buildup of sorbitol in cells triggers the release of taurine (and myo-inositol) from the cells (thus maintaining osmotic balance) and also the inhibition of the re-uptake of taurine by taurine transporter (though this may be a consequence of high blood glucose rather than high cellular sorbitol). This excreted cellular taurine enters the glomerular filtrate, and as a likely result of diabetic kidney tubular damage, is poorly reabsorbed, just as vitamin B1 is, as are many other substances.

Taurine levels in both plasma and urine are lower in diabetics as a result and they clearly need supplementation.

Niacin has been known to occasionally increase blood sugar in diabetics. Certainly something no diabetic would consider doing.

Taking niacin (nicotinic acid, 100 mg several times a day) and taurine (1 gram several times a day) together should suppress that and improve things markedly.

Taking niacin supplements, 100 mg at a time, several times a day, should accelerate the conversion of sorbitol to fructose, which then reacts with hexokinase to make fructose-6-phosphate, and then enters glycolysis for disposal, mostly as lactate in diabetics and as carbon dioxide and water in those who have been cured of diabetes.

As sorbitol concentration is reduced by oxidation to fructose, taurine and myo-inositol will be taken up more readily by cells as the natural osmolytes. Taurine will restore proper ion balances and myo-inositol will support proper hormonal responses.

Taurine will also act to reduce the production of free radicals by stabilizing the structures of the enzymes that most readily produce those free radicals.

Taurine should also result in the production of more taurine-bile salts for better absorption of essential fats, conditionally essential fats, fat-soluble vitamins, and their fat soluble co-nutrients.

Like vitamin B1 supplementation, taurine supplementation reduces the likelihood of getting diabetic complications and the extent of existent diabetic complications including atherosclerosis, nephropathy, and neuropathy.

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