Useful agents in the battle against rogue cells

1. Imagine an agent in a reduced state (called a reducing agent, but really a redox active reagent) that targets a cell that is marked for death with something (such as antibodies) by the adaptive immune system or by another means (such as complement) by the innate immune system.

Before entering the cell, the agent binds a chaperone (a component or processed component of complement?) that was specifically bound to the marked cell, which changes the function of the agent to being primarily a bleach. After the agent is oxidized, as it must be prior to entering the cell, instead of entering the cell, the chaperone directs the agent to oxidize/bleach key (likely involved in communication) molecules on the surface of the marked cell, and the agent is thereby reduced. The agent repeats the cycle an average of N times before it is excreted in urine in exactly the form it was added to the body.

A person measuring the agent in urine would think that the agent had done nothing (compare vitamin C).

Not exactly – it bleached important molecules on the outer surface of cells marked for death.

If this molecule does not exist, it should be invented.

2. Another useful redox active agent would be internalized into the cell marked for death as an agent-chaperone complex. In this case, the chaperone would oxidize the agent every time the agent was reduced by oxidizing its target molecules, the chaperone recharging the bleaching action by using up limited cellular supplies of oxygen. The redox active agent could simply oxidize cellular water, making hydrogen peroxide, raising the hydrogen peroxide concentration to a lethal level inside cells marked for death.

3. A third useful agent would combine the functions of the first two.

An agent somewhat like this may already exist – it may be called “vitamin C” or “vitamin C complex”. But surely, we can do better than nature, can we not?


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