A proper definition of insulin resistance

Some portion of what doctors call insulin resistance is not pathological; it is normal for muscles with negligible glucose demand to not take up additional glucose at a brisk pace, but at a pace that they need to continue to live.


  1. Put a person on a whole foods omnivorous low carbohydrate diet (60 -100 g/d) for at least a week.
  2. Fast a person for at least 24 hours – nothing to eat, just 0 calorie liquids to drink.
  3. Validate that glycogen stores have been reduced at least 75%.
  4. During the last hour of the fast, exercise a person as intensely as his fitness allows.
  5. Give him 75 grams of glucose dissolved in water.
  6. Measure insulin activity and blood glucose vs. time.
  7. If the person’s insulin is low activity, be sure to add an appropriate amount of active insulin and continue to monitor.
  8. Given a proper level of insulin activity, failure to take up this glucose at an appropriate rate is a direct measure of insulin resistance.
  9. Now look for the underlying problems such as high circulating free fatty acids – something that regular fasting (say 19 out of every 24 hours), vigorous exercise, proper nutrition, proper supplementation, and all other things that stimulate mitochondrial respiration will eventually bring back to baseline.

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