Nearly every enzyme has a cofactor

Some enzymes have many cofactors; some have no known cofactors.

Is it a stretch to assume that nearly every cofactor has a cofactor, which we may call a co-cofactor, etc.?

The essential nutrient thiamine has essential nutrient magnesium as a cofactor.

Are there not also conditionally essential co-cofactors?

Even if the first, second, third layers, and every other layer of co-cofactors (which inorganic chemists call “coordination spheres”) is just water, does that not make water activity a critical health variable?

Common on, you know it does. To think that all we need is some 4 dozen essential nutrients to be healthy, we are so naïve it is pathetic.

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