Some enzymes have many cofactors; some have no known cofactors.
Is it a stretch to assume that nearly every cofactor has a cofactor, which we may call a co-cofactor, etc.?
The essential nutrient thiamine has essential nutrient magnesium as a cofactor.
Are there not also conditionally essential co-cofactors?
Even if the first, second, third layers, and every other layer of co-cofactors (which inorganic chemists call “coordination spheres”) is just water, does that not make water activity a critical health variable?
Common on, you know it does. To think that all we need is some 4 dozen essential nutrients to be healthy, we are so naïve it is pathetic.