Dysregulation is the rule in the world and in the human body.
The term “components” refers to nutrients, enzymes, and structures that work together to produce an acceptable effect within the body.
Euregulation occurs ONLY when all the necessary components are present at sufficient concentrations and are assembled into the appropriate structures to function at optimal and appropriate efficiency.
Dysregulation occurs when ANY ONE or more components are deficient or suboptimal.
By definition, dysregulation is therefore the rule.
Apparent euregulation is a form of dysregulation and helps make dysregulation the rule. It occurs when two or more dysregulations more or less cancel each other, so that an observable is within the “reference range.”
Consider blood pressure for example.
The many people who have high blood pressure are dysregulated.
The few people who have low blood pressure are dysregulated.
Many people with normal blood pressure have apparent euregulation. They have offsetting dysregulations within a complex system with many push/pull levers.
A few people with normal blood pressure may have genuine euregulation, in which everything is optimal.
The same could be said of blood sugar, blood cholesterol, etc., etc.
The government uses mass balance of nutrients to set the recommended levels of nutrients. In trusting these numbers, they are assuming genuine euregulation is occurring, yet we know with iron and salt, for example, that the body can keep accumulating dangerously high levels of both. The systems are not euregulated.
When observing mass balances of nutrients, scientists are studying dysregulated systems. Genuine RDAs cannot be determined by mass balance without first proving euregulation. Every nutrient must have its entire DADME network (every nutrient involved in its PROPER digestion, PROPER absorption, PROPER distribution, PROPER metabolism, and PROPER excretion) at optimal levels. And what are the chances of that happening?