Moralists, beware: it seems that serum oxytocin is a marker for general well-being. We know that orgasm temporarily increases serum oxytocin. It is reasonable to assume that frequent orgasm would keep oxytocin, a short-lived protein, higher than infrequent orgasm and be a sign if not a cause of general well-being.
Here’s to frequent orgasm! Moralists, be damned, you fools. You have it backwards. The Namian people have it right. Have at least one orgasm a day – as per “A Rather English Marriage”
Here is the article:
Lower serum oxytocin levels associated with type 2 diabetes, obesity
In the study, the researchers recruited 176 patients from the Diabetes Center of Affiliated Hospital of Jiangsu University in China to determine the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic beta-cell function and inflammation. Eighty-eight patients were newly diagnosed with type 2 diabetes and 88 had normal glucose tolerance.
The researchers found that patients in the type 2 diabetes group had lower serum oxytocin levels than those in the normal glucose tolerance group (P<.01) and participants with obesity had lower circulating levels of serum oxytocin than those classified as normal weight (P<.01). The researchers determine that there was an inverse association between serum oxytocin levels and BMI, waist circumference, waist-to-hip ratio, HbA1c, fasting plasma glucose, 2-hour post-meal plasma glucose, fasting insulin, 2-hour insulin, total cholesterol. Triglycerides, LDL cholesterol, insulin sensitivity and highly sensitive C-reactive protein.
There was a positive association between beta-cell function and serum oxytocin levels (P<.05). In a multiple stepwise regression analysis with oxytocin as the dependent variable, the researchers found that serum oxytocin was association with 2-hour post-meal plasma glucose, BMI and triglycerides.
In logistic regression analyses, it was determine that serum oxytocin was significantly correlated with type 2 diabetes (P<.01).
“In summary, our results indicate for the first time that circulating oxytocin concentrations were significantly decreased in obesity and type 2 diabetes patients,” the researchers wrote. “Moreover, serum oxytocin levels were closely correlated with glycolipid metabolism, insulin resistance, pancreatic beta-cell function and inflammation.”
Disclosure: The study was funded in part by the Medical Science and Technology Development Foundation and International Exchange Program of the Jiangsu Province Department of Health, the National Natural Science Foundation of China, the Natural Science Foundation of Jiangsu Province and the Science and Technology Commission of Zhenjiang City.
Decreased Circulating Levels of Oxytocin in Obesity and Newly Diagnosed Type 2 Diabetic Patients
Oxytocin can affect energy homeostasis and has interesting potential as a metabolic disease therapeutic. We detected serum oxytocin levels in obese (OB) and type 2 diabetes mellitus (T2DM) subjects and investigated the relationships between serum oxytocin levels and glycolipid metabolism, insulin resistance, pancreatic β-cell function, and inflammation.
A total of 176 subjects were enrolled in the study, including 88 patients with newly diagnosed T2DM and 88 subjects with normal glucose tolerance (NGT). NGT and T2DM groups were divided into normal-weight (NW) and OB subgroups. We analyzed the concentrations of oxytocin by ELISA. Oral glucose tolerance testing was done, and hemoglobin A1c (HbA1c), blood lipids, and highly sensitive C-reactive protein (hs-CRP) were also measured. Insulin resistance and pancreatic β-cell function were assessed by homeostasis model assessment (HOMA).
Serum oxytocin levels were lower in the T2DM group than in the NGT group (P < .01). The levels of serum oxytocin in OB subjects were also lower than those in NW subjects (P < .01). Serum oxytocin levels were negatively correlated with body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), HbA1c, fasting plasma glucose (FPG), 2-hour plasma glucose, fasting insulin (FINS), 2-h insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), HOMA of insulin resistance (HOMA-IR), and hs-CRP and positively correlated with HOMA of β-cell function (HOMA-β) (P < .05). Multiple stepwise regression analysis showed that 2-hour plasma glucose, BMI, and TC were associated with serum oxytocin levels (P < .05). Logistic regression analyses demonstrated that serum oxytocin was significantly associated with T2DM (P < .01).
- Department of Endocrinology (W.Q., T.Z., B.T., S.Y., H.H., W.S., R.P., J.W., D.W., L.Y., C.M., G.Y.), Affiliated Hospital of Jiangsu University, Jiangsu 212001, China; and Ruijin Hospital (L.Z.), Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Jiaotong University Medical School, Shanghai 200025, China