A Note on Disease

One of the key problems in understanding the origins of disease is the poor resolution of biological measurements. Day to day coefficients of variation can easily top 10%, while the changes in activity level of the individual components may be less than 10%. This makes getting a smooth baseline rather difficult. When fasting blood sugar has reached the level of pre-diabetes, it is only about 110/70, or 57% above a healthy level. If the 57% deviation were accounted for by one alteration, doctors would have little trouble detecting it reproducibly, and thus “sub-typing” Type II pre-diabetes. However, if this 57% deviation is due to small alterations in say 10 distinct activities, then on average each deviation is only 4.6% and is thus invisible because the precision of the measurements is too low.

Some of these small deviations in key activities may be due to changes in gene expression patterns due to small imbalances (deficiencies or excesses) of nutrients (essential or V3). Others deviations may be due to imbalances of micronutrients in the local environments of the active agents (most often enzymes), resulting in abnormalities in the time-averaged activities. If so, some of these deficiencies should be correctable by correcting dietary errors, resulting in an eventual return to the “normal range of blood sugar.”


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